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Hippocampus mediates nocebo impairment of opioid analgesia through changes in functional connectivity.

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cam.issuedOnline2022-06-16
dc.contributor.authorBingel, Ulrike
dc.contributor.authorWiech, Katja
dc.contributor.authorRitter, Christoph
dc.contributor.authorWanigasekera, Vishvarani
dc.contributor.authorNí Mhuircheartaigh, Roisin
dc.contributor.authorLee, Michael C
dc.contributor.authorPloner, Markus
dc.contributor.authorTracey, Irene
dc.contributor.orcidBingel, Ulrike [0000-0002-9528-3204]
dc.contributor.orcidWiech, Katja [0000-0002-5062-1046]
dc.contributor.orcidRitter, Christoph [0000-0001-8899-6444]
dc.contributor.orcidWanigasekera, Vishvarani [0000-0001-9922-8993]
dc.contributor.orcidNí Mhuircheartaigh, Roisin [0000-0003-0567-4939]
dc.contributor.orcidLee, Michael C [0000-0002-5838-2916]
dc.contributor.orcidPloner, Markus [0000-0002-7767-7170]
dc.contributor.orcidTracey, Irene [0000-0003-4134-6115]
dc.date.accessioned2022-06-17T08:00:37Z
dc.date.available2022-06-17T08:00:37Z
dc.date.issued2022-07
dc.date.submitted2022-01-25
dc.date.updated2022-06-17T08:00:37Z
dc.description.abstractThe neural mechanisms underlying placebo analgesia have attracted considerable attention over the recent years. In contrast, little is known about the neural underpinnings of a nocebo-induced increase in pain. We previously showed that nocebo-induced hyperalgesia is accompanied by increased activity in the hippocampus that scaled with the perceived level of anxiety. As a key node of the neural circuitry of perceived threat and fear, the hippocampus has recently been proposed to coordinate defensive behaviour in a context-dependent manner. Such a role requires close interactions with other regions involved in the detection of and responses to threat. Here, we investigated the functional connectivity of the hippocampus during nocebo-induced hyperalgesia. Our results show an increase in functional connectivity between hippocampus and brain regions implicated in the processing of sensory-discriminative aspects of pain (posterior insula and primary somatosensory/motor cortex) as well as the periaqueductal grey. This nocebo-induced increase in connectivity scaled with an individual's increase in anxiety. Moreover, hippocampus connectivity with the amygdala was negatively correlated with the pain intensity reported during nocebo hyperalgesia relative to the placebo condition. Our findings suggest that the hippocampus links nocebo-induced anxiety to a heightened responsiveness to nociceptive input through changes in its crosstalk with pain-modulatory brain areas.
dc.identifier.doi10.17863/CAM.85604
dc.identifier.eissn1460-9568
dc.identifier.issn0953-816X
dc.identifier.otherejn15687
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338193
dc.languageen
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1111/ejn.15687
dc.subjectamygdala
dc.subjectanxiety
dc.subjectbrain
dc.subjecthippocampal
dc.subjectpain
dc.subjectAnalgesia
dc.subjectAnalgesics, Opioid
dc.subjectHippocampus
dc.subjectHumans
dc.subjectHyperalgesia
dc.subjectMagnetic Resonance Imaging
dc.subjectNocebo Effect
dc.subjectPain
dc.titleHippocampus mediates nocebo impairment of opioid analgesia through changes in functional connectivity.
dc.typeArticle
dcterms.dateAccepted2022-05-04
prism.publicationNameEur J Neurosci
pubs.funder-project-idDeutsche Forschungsgemeinschaft (422744262‐TRR 289)
pubs.funder-project-idWellcome Trust (203139/Z/16/Z)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1111/ejn.15687

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