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Digit ratio (2D:4D) and maternal testosterone-to-estradiol ratio measured in early pregnancy

Published version
Peer-reviewed

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Authors

Richards, Gareth 
Aydin, Ezra 
Tsompanidis, Alex 
Padaigaitė, Eglė 
Austin, Topun 

Abstract

jats:titleAbstract</jats:title>jats:pThe ratio of index to ring finger (2D:4D) has been hypothesised to indicate prenatal androgen exposure, yet evidence for its validity is lacking. We report the first pre-registered study to investigate mothers’ early pregnancy sex hormone concentrations in relation to their children’s digit ratios measured at 18–22-month follow-up. Although the testosterone (T) to estradiol (E) ratio correlated negatively with right hand digit ratio (R2D:4D) and directional asymmetry (right-minus-left) in digit ratio (Djats:sub[R−L]</jats:sub>), neither effect remained statistically significant once demographic and obstetric covariates were controlled for. Nevertheless, the multivariate level of analysis did reveal that T correlated positively with left hand digit ratio (L2D:4D) and negatively with Djats:sub[R−L]</jats:sub>. However, the first of these effects is in the opposite direction to that predicted by theory. Taken together, the results of our study suggest research with larger samples is required to determine whether digit ratios are valid proxies for maternal sex hormone exposure.</jats:p>

Description

Funder: NIHR Cambridge Biomedical Research Centre; doi: http://dx.doi.org/10.13039/501100018956


Funder: NIHR Brain Injury MedTech Co-operative


Funder: Autism Research Trust


Funder: Simons Foundation Autism Research Initiative; doi: http://dx.doi.org/10.13039/100014370


Funder: Templeton World Charitable Fund


Funder: Medical Research Council; doi: http://dx.doi.org/10.13039/501100000265


Funder: NIHR Collaboration for Leadership in Applied Health Research and Care East of England at Cambridgeshire and Peterborough NHS Foundation Trust


Funder: Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394 for the project AIMS-2-TRIALS

Keywords

Article, /631/136, /692/163, /631/181/2806, article

Journal Title

Scientific Reports

Conference Name

Journal ISSN

2045-2322

Volume Title

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (214322\Z\18\Z)