Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor
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Peer-reviewed
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Abstract
A procedure that yields pyrazinamide as a fine white powder is presented. A glass column reactor is used containing Celite and manganese dioxide and is mounted vertically in a heating jacket. Following the procedure are notes on the instruments and chemicals used and required. The chapter concludes with a discussion on the general concepts regarding preparation of pyrazinamide.
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Organic Syntheses
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Journal ISSN
0078-6209
2333-3553
2333-3553
Volume Title
94
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Organic Syntheses Inc.
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Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
We are grateful to Pfizer Worldwide Research and Development (CB), the Croucher Foundation and Cambridge Trust (SHL) and the EPSRC (SVL, grant n° EP/K009494/1 and EP/M004120/1) for financial support.