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Medical symptoms and conditions in autistic women.

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cam.issuedOnline2021-06-29
dc.contributor.authorSimantov, Tslil
dc.contributor.authorPohl, Alexa
dc.contributor.authorTsompanidis, Alexandros
dc.contributor.authorWeir, Elizabeth
dc.contributor.authorLombardo, Michael V
dc.contributor.authorRuigrok, Amber
dc.contributor.authorSmith, Paula
dc.contributor.authorAllison, Carrie
dc.contributor.authorBaron-Cohen, Simon
dc.contributor.authorUzefovsky, Florina
dc.contributor.orcidSimantov, Tslil [0000-0002-6562-6288]
dc.contributor.orcidAllison, Carrie [0000-0003-2272-2090]
dc.contributor.orcidUzefovsky, Florina [0000-0003-4571-2514]
dc.date.accessioned2022-02-04T18:17:21Z
dc.date.available2022-02-04T18:17:21Z
dc.date.issued2022-02
dc.date.updated2022-02-04T18:17:21Z
dc.descriptionFunder: National Institute for Psychobiology in Israel, Hebrew University of Jerusalem; FundRef: https://doi.org/10.13039/501100001739
dc.descriptionFunder: Templeton World Charitable Foundation
dc.descriptionFunder: NIHR Biomedical Research Centre in Cambridge
dc.descriptionFunder: Autism Research Trust
dc.description.abstractSex-steroids, such as testosterone, are thought to be one of the biological factors implicated in autism. This relies on the sex bias in the diagnosis of autism (boys are approximately four times more likely to be diagnosed than girls) and findings of associations with fetal testosterone levels in traits and abilities related to autism. The current study aimed to examine the association between medical conditions and physical symptoms, which tend to manifest in adulthood, and autism in females. Moreover, we examined their association with autistic traits throughout the spectrum. We focused on autistic women because there is little research focusing on the healthcare needs of autistic women, but those that exist suggest heightened vulnerability, and lower access to medical care. We find that conditions related to steroid hormones function are more frequent in autistic women and that they correlate with autistic traits. Specifically, we found that body mass index, reproductive system diagnoses, prediabetes symptoms, irregular puberty onset, and menstrual irregularities were significantly more frequent in autistic women and were significantly correlated with autistic traits in neurotypical women. The findings have important implications for raising awareness in autistic women of the possibility of medical conditions which might need medical attention. In addition, healthcare providers should consider these associations when performing healthcare maintenance checks and/or screening for autism.
dc.identifier.doi10.17863/CAM.81077
dc.identifier.eissn1461-7005
dc.identifier.issn1362-3613
dc.identifier.other10.1177_13623613211022091
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333659
dc.languageen
dc.language.isoeng
dc.publisherSAGE Publications
dc.publisher.urlhttp://dx.doi.org/10.1177/13623613211022091
dc.subjectautism
dc.subjectclinical
dc.subjectfemales
dc.subjectpuberty
dc.subjectsteroids
dc.subjecttestosterone
dc.subjectAdult
dc.subjectAutism Spectrum Disorder
dc.subjectAutistic Disorder
dc.subjectBody Mass Index
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPhenotype
dc.titleMedical symptoms and conditions in autistic women.
dc.typeArticle
dcterms.dateAccepted2021-05-14
prism.endingPage388
prism.issueIdentifier2
prism.publicationNameAutism
prism.startingPage373
prism.volume26
pubs.funder-project-idWellcome Trust (award number RG69312)
pubs.funder-project-idWellcome Trust (grant number RNAG/528)
pubs.funder-project-idInnovative Medicines Initiative 2 Joint Undertaking (JU) (grant agreement No 777394)
rioxxterms.freetoread.startdate2021-06-29
rioxxterms.licenseref.startdate2021-06-29
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1177/13623613211022091

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