dc.contributor.author	de Goffau, Marcus C.
dc.contributor.author	Jallow, Amadou T.
dc.contributor.author	Sanyang, Chilel
dc.contributor.author	Prentice, Andrew M.
dc.contributor.author	Meagher, Niamh
dc.contributor.author	Price, David J.
dc.contributor.author	Revill, Peter A.
dc.contributor.author	Parkhill, Julian
dc.contributor.author	Pereira, Dora I. A.
dc.contributor.author	Wagner, Josef
dc.contributor.orcid	Prentice, Andrew M. [0000-0001-5389-451X]
dc.contributor.orcid	Parkhill, Julian [0000-0002-7069-5958]
dc.contributor.orcid	Wagner, Josef [0000-0003-1204-7765]
dc.date.accessioned	2022-01-10T12:46:32Z
dc.date.available	2022-01-10T12:46:32Z
dc.date.issued	2021-12-31
dc.date.submitted	2021-02-07
dc.date.updated	2022-01-10T12:46:31Z
dc.description	Funder: MRC Unit The Gambia/MRC International Nutrition Group by the UK MRC and the UK Department for the International Development
dc.description	Funder: Bill & Melinda Gates Foundation Grand Challenges New Interventions in Global Health award
dc.description.abstract	Abstract: Distinct bacterial trophic networks exist in the gut microbiota of individuals in industrialized and non-industrialized countries. In particular, non-industrialized gut microbiomes tend to be enriched with Prevotella species. To study the development of these Prevotella-rich compositions, we investigated the gut microbiota of children aged between 7 and 37 months living in rural Gambia (616 children, 1,389 stool samples, stratified by 3-month age groups). These infants, who typically eat a high-fibre, low-protein diet, were part of a double-blind, randomized iron intervention trial (NCT02941081) and here we report the secondary outcome. We found that child age was the largest discriminating factor between samples and that anthropometric indices (collection time points, season, geographic collection site, and iron supplementation) did not significantly influence the gut microbiome. Prevotella copri, Faecalibacterium prausnitzii and Prevotella stercorea were, on average, the most abundant species in these 1,389 samples (35%, 11% and 7%, respectively). Distinct bacterial trophic network clusters were identified, centred around either P.stercorea or F.prausnitzii and were found to develop steadily with age, whereas P.copri, independently of other species, rapidly became dominant after weaning. This dataset, set within a critical gut microbial developmental time frame, provides insights into the development of Prevotella-rich gut microbiomes, which are typically understudied and are underrepresented in western populations.
dc.identifier.doi	10.17863/CAM.79950
dc.identifier.eissn	2058-5276
dc.identifier.other	s41564-021-01023-6
dc.identifier.other	1023
dc.identifier.uri	https://www.repository.cam.ac.uk/handle/1810/332500
dc.language	en
dc.publisher	Nature Publishing Group UK
dc.subject	Article
dc.subject	/631/326/2565/855
dc.subject	/631/326/2565/2134
dc.subject	/45/23
dc.subject	/45/22
dc.subject	/45/77
dc.subject	article
dc.title	Gut microbiomes from Gambian infants reveal the development of a non-industrialized Prevotella -based trophic network
dc.type	Article
dcterms.dateAccepted	2021-11-11
prism.endingPage	144
prism.issueIdentifier	1
prism.publicationName	Nature Microbiology
prism.startingPage	132
prism.volume	7
pubs.funder-project-id	Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) (OPP1140952)
rioxxterms.licenseref.uri	http://creativecommons.org/licenses/by/4.0/
rioxxterms.version	VoR
rioxxterms.versionofrecord	10.1038/s41564-021-01023-6

Gut microbiomes from Gambian infants reveal the development of a non-industrialized Prevotella -based trophic network

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