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Why TAPBPR? Implications of an additional player in MHC class I peptide presentation

Accepted version
Peer-reviewed

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Article

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Authors

Hafstrand, Ida 
Aflalo, aure 

Abstract

The peptide editor TAPBPR is the newest member of the major histocompatibility complex class I (MHC-I) antigen processing and presentation pathway. Since 2013, studies have explored the functions and mechanisms of action of this tapasin homolog. Here, we review the key insights gained from structural studies of the TAPBPR:MHC-I complex and the involvement of the TAPBPR loop in peptide exchange. However, despite recent advances, the question still remains: why do we need TAPBPR? The recent appreciation that different MHC-I allotypes vary in their ability to interact with TAPBPR, together with a role for TAPBPR in alternative presentation pathways highlights that much remains unknown concerning the biological need for TAPBPR.

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Journal Title

Current Opinion in Immunology

Conference Name

Journal ISSN

0952-7915

Volume Title

Publisher

Elsevier
Sponsorship
Cancer Research UK (25343)
Wellcome Trust (219479/Z/19/Z)