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Metabolic imaging with deuterium labeled substrates.

Published version
Peer-reviewed

Type

Article

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Authors

Chen Ming Low, Jacob 
Wright, Alan J 
Hesse, Friederike 
Cao, Jianbo 
Brindle, Kevin M 

Abstract

Deuterium metabolic imaging (DMI) is an emerging clinically-applicable technique for the non-invasive investigation of tissue metabolism. The generally short T1 values of 2H-labeled metabolites in vivo can compensate for the relatively low sensitivity of detection by allowing rapid signal acquisition in the absence of significant signal saturation. Studies with deuterated substrates, including [6,6'-2H2]glucose, [2H3]acetate, [2H9]choline and [2,3-2H2]fumarate have demonstrated the considerable potential of DMI for imaging tissue metabolism and cell death in vivo. The technique is evaluated here in comparison with established metabolic imaging techniques, including PET measurements of 2-deoxy-2-[18F]fluoro-d-glucose (FDG) uptake and 13C MR imaging of the metabolism of hyperpolarized 13C-labeled substrates.

Description

Keywords

Deuterium, Hyperpolarized-(13)C, Metabolism, PET, Deuterium, Magnetic Resonance Imaging, Cell Death

Journal Title

Prog Nucl Magn Reson Spectrosc

Conference Name

Journal ISSN

0079-6565
1873-3301

Volume Title

Publisher

Elsevier BV
Sponsorship
Cancer Research UK (C14303/A17197)
Cancer Research UK (CB4100)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (858149)
MRC (MR/V029452/1)
Cancer Research UK (C96/A25177)