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The stereocontrolled total synthesis of polyketide natural products: A thirty-year journey

Accepted version
Peer-reviewed

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Type

Article

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Authors

Stockdale, TP 
Lam, NYS 
Anketell, MJ 

Abstract

jats:titleAbstract</jats:title> jats:pThe diverse and complex structures of polyketide natural products have stimulated the imagination of synthetic chemists for decades. Captivated by their often impressive biological activities and their dazzling array of stereochemically-rich motifs, we have been motivated to achieve their efficient and stereocontrolled total synthesis. This review captures snapshots from our thirty-year foray into the total synthesis of 18 polyketide natural products, detailing the unique challenges, discoveries and revelations made en route to eventual success. Notably, crucial to each of these campaigns was the judicious application of highly selective aldol reactions to iteratively configure the densely oxygenated stereoclusters that characterise this fascinating class of bioactive natural products.</jats:p>

Description

Keywords

Polyketide, Macrolide, Total synthesis

Journal Title

Bulletin of the Chemical Society of Japan

Conference Name

Journal ISSN

0009-2673
1348-0634

Volume Title

94

Publisher

Oxford University Press (OUP)

Rights

All rights reserved