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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Published version
Peer-reviewed

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Authors

Dienstmann, Rodrigo 
Rachid, Maan Haj 
Boekel, Jorrit 
Lopez-Fernandez, Adria  ORCID logo  https://orcid.org/0000-0002-2844-5998

Abstract

There is a growing need for systems that efficiently support the work of medical teams at the precision-oncology point of care. Here, we present the implementation of the Molecular Tumor Board Portal (MTBP), an academic clinical decision support system developed under the umbrella of Cancer Core Europe that creates a unified legal, scientific and technological platform to share and harness next-generation sequencing data. Automating the interpretation and reporting of sequencing results decrease the need for time-consuming manual procedures that are prone to errors. The adoption of an expert-agreed process to systematically link tumor molecular profiles with clinical actions promotes consistent decision-making and structured data capture across the connected centers. The use of information-rich patient reports with interactive content facilitates collaborative discussion of complex cases during virtual molecular tumor board meetings. Overall, streamlined digital systems like the MTBP are crucial to better address the challenges brought by precision oncology and accelerate the use of emerging biomarkers.

Description

Keywords

Decision Support Systems, Clinical, High-Throughput Nucleotide Sequencing, Humans, Medical Oncology, Neoplasms, Precision Medicine

Journal Title

Nat Cancer

Conference Name

Journal ISSN

2662-1347
2662-1347

Volume Title

3

Publisher

Springer Science and Business Media LLC
Sponsorship
European Commission Horizon 2020 (H2020) ERC (965397)
Medical Research Council (MR/P012442/1)
Cancer Research UK (16942)
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