CLN8 safeguards lysosome biogenesis.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Luzio, J Paul
Abstract
Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.
Description
Keywords
Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Lysosomes
Journal Title
Nat Cell Biol
Conference Name
Journal ISSN
1465-7392
1476-4679
1476-4679
Volume Title
20
Publisher
Springer Science and Business Media LLC