Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Type
Change log
Authors
Abstract
BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.
Description
Keywords
Journal Title
Conference Name
Journal ISSN
1532-1827
Volume Title
Publisher
Publisher DOI
Sponsorship
National Institutes of Health (NIH) (via H Lee Moffitt Cancer Center & Research Institute) (SUBAWARD # 10-15915-01-03-G2)
Cancer Research Uk (None)
National Cancer Institute (U19CA148065)
National Cancer Institute (U19CA148537)
Cancer Research UK (12014)
Cancer Research UK (10118)
National Cancer Institute (R01CA128978)
Cancer Research Uk (None)
Cancer Research Uk (None)
Cancer Research UK (16565)