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An active DNA-based nanoprobe for photoacoustic pH imaging.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Baumann, Kevin N 
Fux, Alexandra C 
Bohndiek, Sarah E 
Hernández-Ainsa, Silvia 

Abstract

We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.

Description

Keywords

0912 Materials Engineering, Nanotechnology, Bioengineering, Cancer, Genetics

Journal Title

Chem Commun (Camb)

Conference Name

Journal ISSN

1359-7345
1364-548X

Volume Title

54

Publisher

Royal Society of Chemistry (RSC)
Sponsorship
European Commission (630729)
Cancer Research Uk (None)
Cancer Research Uk (None)