An active DNA-based nanoprobe for photoacoustic pH imaging.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Baumann, Kevin N
Fux, Alexandra C
Joseph, James https://orcid.org/0000-0001-6270-2559
Bohndiek, Sarah E
Hernández-Ainsa, Silvia
Abstract
We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.
Description
Keywords
0912 Materials Engineering, Nanotechnology, Bioengineering, Cancer, Genetics
Journal Title
Chem Commun (Camb)
Conference Name
Journal ISSN
1359-7345
1364-548X
1364-548X
Volume Title
54
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
Sponsorship
European Commission (630729)
Cancer Research Uk (None)
Cancer Research Uk (None)
Cancer Research Uk (None)
Cancer Research Uk (None)