An active DNA-based nanoprobe for photoacoustic pH imaging.

We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.

Keywords

40 Engineering, 4003 Biomedical Engineering, Cancer, Bioengineering, Nanotechnology, Biomedical Imaging, Cancer

Journal Title

Chem Commun (Camb)

Journal ISSN

1359-7345
1364-548X

Volume Title

54

Publisher

Royal Society of Chemistry (RSC)

Publisher DOI

https://doi.org/10.1039/c8cc04007a

Rights and licensing

Except where otherwised noted, this item's license is described as Attribution 4.0 International

Sponsorship

European Commission (630729)
Cancer Research Uk (None)
Cancer Research Uk (None)

Collections

University of Cambridge Research Outputs (Articles and Conferences)