Research Data - Oncology
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Item Open Access Primary data for BJC Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivoGriffiths, JR; Lee, Shen-Han; McIntyre, Dominick John; Honess, Davina Jean; Hulikova, Alzbeta; Pacheco-Torres, Jesus; Cerdan, Sebastian; Swietach, Pawel; Harris, Adrian L; Griffiths, John [0000-0001-7369-6836]; McIntyre, Dominick [0000-0002-0269-6545]Item Open Access Dataset for: First-in-human pilot study of snapshot multispectral endoscopy for early detection of Barrett's-related neoplasia.Waterhouse, Dale; Bano, Sophia; Januszewicz, Wladyslaw; Stoyanov, Dan; Fitzgerald, Rebecca; Di Pietro, Massimiliano; Bohndiek, Sarah; Fitzgerald, Rebecca [0000-0002-3434-3568]; Di Pietro, Massimiliano [0000-0003-4866-7026]; Bohndiek, Sarah [0000-0003-0371-8635]Item Open Access Research data supporting 'Robustness to misalignment of low-cost, compact wide-field quantitative phase imaging architectures'Fitzpatrick, Catherine; Gordon, George SD; Wilson, Abby; Sawyer, Travis; Christopher, Peter; Bohndiek, Sarah; Wilkinson, T; Fitzpatrick, Catherine [0000-0002-8866-9547]; Gordon, George [0000-0002-7333-5106]; Bohndiek, Sarah [0000-0003-0371-8635]; Wilkinson, Timothy [0000-0001-8885-1288]Item Open Access Research data supporting 'Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial'Fitzgerald, Rebecca; Fitzgerald, Rebecca [0000-0002-3434-3568]Item Open Access Ovarian Cancer Association Consortium East Asian GWAS summary resultsPharoah, PDP; Pharoah, Paul [0000-0001-8494-732X]Item Open Access Research data supporting "Common variation in genes encoding small GTPases and ovarian cancer risk": GTPases candidate gene SNP genotypesPharoah, PDP; Pharoah, Paul [0000-0001-8494-732X]Item Open Access 8q24 COGS fine mapping dataPharoah, PDP; Pharoah, Paul [0000-0001-8494-732X]Item Open Access Research data supporting "A clinically translatable hyperspectral endoscopy (HySE) system for imaging the gastrointestinal tract"Yoon, Jonghee; Joseph, James; Waterhouse, Dale; Luthman, Siri; Gordon, George; Di Pietro, Massimiliano; Januszewicz, Wladyslaw; Fitzgerald, Rebecca; Bohndiek, Sarah; Yoon, Jonghee [0000-0003-3886-2792]; Joseph, James [0000-0001-6270-2559]; Waterhouse, Dale [0000-0001-5530-6857]; Gordon, George [0000-0002-7333-5106]; Di Pietro, Massimiliano [0000-0003-4866-7026]; Fitzgerald, Rebecca [0000-0002-3434-3568]; Bohndiek, Sarah [0000-0003-0371-8635]Item Open Access Research data supporting “Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity”(University of Cambridge) Flint, T; Janowitz, T; Connell, C; Roberts, E; Denton, A; Coll, A; Jodrell, D; Fearon, DItem Open Access Research data supporting "Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer"(2015-05-08) Candido do Reis, Francisco J.; Lynn, Stuart; Ali, H. Raza; Eccles, Diana; Hanby, Andrew; Provenzano, Elena; Caldas, Carlos; Howat, William J; McDuffus, Leigh-Anne; Liu, Bin; Daley, Frances; Coulson, Penny; J.Vyas, Rupesh; Harris, Leslie M.; Owens, Joanna M.; M. Amy F.; McQuillan, Janette P.; Paterson, Andy M.; Hirji, Zohra; Christie, Sarah K.; Holmes, Amber R.; Schmidt, Marjanka K.; Garcia-Closas, Montserrat; Easton, Douglas F.; Bolla, Manjeet K.; Wang, Qin; Benitez, Javier; Milne, Roger L.; Mannermaa, Arto; Couch, Fergus; Devilee, Peter; Tollenaar, Robert A. E. M.; Seynaeve, Caroline; Cox, Angela; Cross, Simon S.; Blows, Fiona M.; Sanders, Joyce; Groot, Renate de; Figueroa, Jonine; Sherman, Mark; Hooning, Maartje; Brenner, Hermann; Holleczek, Bernd; Stegmaier, Christa; Lintott, Chris; Pharoah, Paul D. P.Item Open Access Chromosomal instability determines taxane sensitivity - supplementary materials(2009-04-24T13:33:28Z) Swanton, Charles; Nicke, Barbara; Schuett, Marion; Eklund, Aron C.; Ng, Charlotte; Li, Qiyuan; Hardcastle, Thomas; Lee, Alvin; Roy, Rajat; East, Philip; Kschischo, Maik; Endesfelder, David; Wylie, Paul; Kim, Se Nyun; Chen, Jie-Guang; Howell, Michael; Ried, Thomas; Habermann, Jens K.; Auer, Gert; Brenton, James D.; Szallasi, Zoltan; Downward, JulianMicrotubule-stabilizing (MTS) agents, such as taxanes, are important chemotherapeutics with a poorly understood mechanism of action. We identified a set of genes repressed in multiple cell lines in response to MTS agents and observed that these genes are overexpressed in tumors exhibiting chromosomal instability (CIN). Silencing 22/50 of these genes, many of which are involved in DNA repair, caused cancer cell death, suggesting that these genes are involved in the survival of aneuploid cells. Overexpression of these ‘‘CIN-survival’’ genes is associated with poor outcome in estrogen receptor–positive breast cancer and occurs frequently in basal-like and Her2-positive cases. In diploid cells, but not in chromosomally unstable cells, paclitaxel causes repression of CIN-survival genes, followed by cell death. In the OV01 ovarian cancer clinical trial, a high level of CIN was associated with taxane resistance but carboplatin sensitivity, indicating that CIN may determine MTS response in vivo. Thus, pretherapeutic assessment of CIN may optimize treatment stratification and clinical trial design using these agents.