Inside and out; the activities of senescence in cancer
Nature Reviews Cancer
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Perez-Mancera, P. A., Young, A., & Narita, M. (2014). Inside and out; the activities of senescence in cancer. Nature Reviews Cancer, 14 547-558. https://doi.org/10.1038/nrc3773
The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality. Both the cell autonomous and the non-cell autonomous activities of senescent cells create spatio-temporally dynamic and context-dependent tissue reactions. For example, the senescence-associated secretory phenotype (SASP) provokes not only tumour suppressive but also tumour promoting responses. Senescence is now increasingly considered as an integrated and widespread component that is potentially important for tumour development, suppression and the response to therapy.
Cancer Research UK (C14303_do not transfer)
External DOI: https://doi.org/10.1038/nrc3773
This record's URL: https://www.repository.cam.ac.uk/handle/1810/245910