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dc.contributor.authorGünesdogan, Ufuken
dc.contributor.authorMagnúsdóttir, Ernaen
dc.contributor.authorSurani, Azimen
dc.date.accessioned2014-10-13T13:18:01Z
dc.date.available2014-10-13T13:18:01Z
dc.date.issued2014-12-05en
dc.identifier.citationPhilosophical Transactions of the Royal Society B: Biological Sciences 369: 20130543. http://dx.doi.org/10.1098/rstb.2013.0543en
dc.identifier.issn0962-8436
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246160
dc.description.abstractDuring embryonic development, the foundation of the germline is laid by the specification of primordial germ cells (PGCs) from the postimplantation epiblast via BMP and WNT signalling. While the majority of epiblast cells undergo differentiation towards somatic cell lineages, PGCs initiate a unique cellular programme driven by the cooperation of the transcription factors BLIMP1, PRDM14 and AP2g. These factors synergistically suppress the ongoing somatic differentiation and drive the re-expression of pluripotency and germ cell-specific genes accompanied by global epigenetic changes. However, an unresolved question is how postimplantation epiblast cells acquire the developmental competence for the PGC fate downstream of BMP/WNT signalling. One emerging concept is that transcriptional enhancers might play a central role in the establishment of developmental competence and the execution of cell fate determination. Here, we discuss recent advances on the specification and reprogramming of PGCs thereby highlighting the concept of enhancer function.
dc.description.sponsorshipU.G. is supported by a Marie Curie Intra-European fellowship. E.M. is supported by the Icelandic Research Fund. M.A.S. is supported by the Wellcome Trust (WT096738).
dc.languageEnglishen
dc.language.isoenen
dc.publisherRoyal Society Publishing
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.titlePrimoridal germ cell specification: a context-dependent cellular differentiation eventen
dc.typeArticle
dc.description.versionThis is the final version. It was first published by Royal Society Publishing at http://rstb.royalsocietypublishing.org/content/369/1657/20130543en
prism.number20130543en
prism.publicationDate2014en
prism.publicationNamePhilosophical Transactions of the Royal Society Ben
prism.volume369en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderERC
dc.rioxxterms.projectidWT096738
rioxxterms.versionofrecord10.1098/rstb.2013.0543en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-12-05en
dc.contributor.orcidSurani, Azim [0000-0002-8640-4318]
dc.identifier.eissn1471-2970
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales