Total synthesis of jiadifenolide.
Dalby, Stephen M
Angew Chem Int Ed Engl
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Paterson, I., Xuan, M., & Dalby, S. M. (2014). Total synthesis of jiadifenolide.. Angew Chem Int Ed Engl, 53 7286-7289. https://doi.org/10.1002/anie.201404224
As a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small-molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adventurous samarium-mediated cyclization reaction to establish the tricyclic core and the adjacent C5 and C6 quaternary stereocenters.
cyclization, neurological agents, samarium, terpenoids, total synthesis
We thank Clare College Cambridge (Fellowship to S.M.D.) and the EPSRC UK National Mass Spectrometry Facility at Swansea.
External DOI: https://doi.org/10.1002/anie.201404224
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246182
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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