Diabetes mellitus and pancreatitis in dogs and cats – cause or effect?
The Journal of Small Animal Practice
Wiley on behalf of the British Small Animal Veterinary Association
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Davison, L. (2015). Diabetes mellitus and pancreatitis in dogs and cats – cause or effect?. The Journal of Small Animal Practice, 56 50-59. https://doi.org/10.1111/jsap.12295
Diabetes mellitus (DM) and pancreatitis are two distinct diseases encountered commonly in small animal practice. Whilst the clinical signs of DM are usually unmistakeable, a firm diagnosis of pancreatitis can prove more elusive, as clinical signs are often variable. Over the past 10-15 years, despite the fact that the clinical signs of DM are remarkably consistent, it has become more apparent that the underlying pathology of DM in dogs and cats is heterogeneous, with exocrine pancreatic inflammation accompanying DM in a number of cases. However, the question remains as to whether the DM causes the pancreatitis or whether, conversely, the pancreatitis leads to DM - as there is evidence to support both scenarios. The concurrence of DM and pancreatitis has clinical implications for case management as such cases may follow a more difficult clinical course, with their glycaemic control being ‘brittle’ as a result of variation in the degree of pancreatic inflammation. Problems may also arise if abdominal pain or vomiting lead to anorexia. In addition, diabetic cases with pancreatitis are at risk of developing exocrine pancreatic insufficiency in the following months to years, which can complicate their management further.
External DOI: https://doi.org/10.1111/jsap.12295
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246203