Nanofibrous hydrogel composites as mechanically robust tissue engineering scaffolds
Offeddu, Giovanni S
Trends in Biotechnology
Cell Press (Elsevier)
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Butcher, A., Offeddu, G. S., & Oyen, M. (2014). Nanofibrous hydrogel composites as mechanically robust tissue engineering scaffolds. Trends in Biotechnology, 32 564-570. https://doi.org/10.1016/j.tibtech.2014.09.001
Hydrogels closely resemble the extracellular matrix and can support cell proliferation while new tissue is formed, making them materials of choice as tissue engineering scaffolds. However, their sometimes poor mechanical properties can hinder their application. The addition of meshes of nanofibers embedded in their matrix forms a composite that draws from the advantages of both components. As these materials are still in the early stages of development, there is a lack of uniformity across methods for characterizing their mechanical properties. A simple metric to enable comparisons between materials is proposed. The fibrous constituent improves the mechanical properties of the hydrogel, while the biocompatibility and functionality of the gels is maintained or even improved.
hydrogel, electrospinning, mechanical testing, biocompatibility, nanofibers, composites
The authors acknowledge the support of the EPSRC through a doctoral training award (ALB) and via the Nano Science and Technology Doctoral Training Centre (NanoDTC), EP/G037221/1 (GSO).
External DOI: https://doi.org/10.1016/j.tibtech.2014.09.001
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246499