Shared transcription factors contribute to distinct cell fates
Ng, Felicia SL
Calero-Nieto, Fernando J
Taylor & Francis
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Ng, F. S., Calero-Nieto, F. J., & Gottgens, B. (2015). Shared transcription factors contribute to distinct cell fates. Transcription, 5 (e978173)https://doi.org/10.4161/21541264.2014.978173
Genome-wide transcription factor (TF) binding profiles differ dramatically between cell types. However, not much is known about the relationship between cell-type-specific binding patterns and gene expression. A recent study demonstrated how the same TFs can have functional roles when binding to largely non-overlapping genomic regions in hematopoietic progenitor and mast cells. Cell-type specific binding profiles of shared TFs are therefore not merely the consequence of opportunistic and functionally irrelevant binding to accessible chromatin, but instead have the potential to make meaningful contributions to cell-type specific transcriptional programs.
binding motif, hematopoiesis, mast cell, regression model, TF, transcription factor, ChIP-seq, ChIP sequencing, RNA-seq, RNA sequencing, GAM, generalized additive model
Work in the authors’ laboratory is supported by grants from Leukaemia and Lymphoma Research, the MRC, BBSRC, the Leukaemia and Lymphoma Society, Cancer Research UK, the National Institute for Health Research Cambridge Biomedical Research Centre, and core support grants by the Wellcome Trust to the Cambridge Institute for Medical Research and Wellcome Trust & MRC Cambridge Stem Cell Institute. FSLN is the recipient of a Yousef Jameel scholarship.
Cancer Research UK (12765)
Leukaemia & Lymphoma Research (12029)
Wellcome Trust (097922/Z/11/Z)
Leukemia & Lymphoma Society (7001-12)
External DOI: https://doi.org/10.4161/21541264.2014.978173
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246545
Attribution 2.0 UK: England & Wales, http://creativecommons.org/licenses/by/2.0/uk/