Shared transcription factors contribute to distinct cell fates.
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Authors
Ng, Felicia SL
Calero-Nieto, Fernando J
Göttgens, Berthold
Abstract
Genome-wide transcription factor (TF) binding profiles differ dramatically between cell types. However, not much is known about the relationship between cell-type-specific binding patterns and gene expression. A recent study demonstrated how the same TFs can have functional roles when binding to largely non-overlapping genomic regions in hematopoietic progenitor and mast cells. Cell-type specific binding profiles of shared TFs are therefore not merely the consequence of opportunistic and functionally irrelevant binding to accessible chromatin, but instead have the potential to make meaningful contributions to cell-type specific transcriptional programs.
Description
Keywords
ChIP-seq, ChIP sequencing, GAM, generalized additive model, RNA-seq, RNA sequencing, TF, transcription factor, binding motif, hematopoiesis, mast cell, regression model, Animals, Cell Lineage, Gene Expression, Humans, Organ Specificity, Transcription Factors
Journal Title
Transcription
Conference Name
Journal ISSN
2154-1264
2154-1272
2154-1272
Volume Title
5
Publisher
Informa UK Limited
Publisher DOI
Rights
Attribution 2.0 UK: England & Wales
Sponsorship
Cancer Research Uk (None)
Biotechnology and Biological Sciences Research Council (BB/I00050X/1)
Leukaemia & Lymphoma Research (12029)
Wellcome Trust (097922/Z/11/Z)
Medical Research Council (MC_PC_12009)
Leukemia & Lymphoma Society (7001-12)
Biotechnology and Biological Sciences Research Council (BB/I00050X/1)
Leukaemia & Lymphoma Research (12029)
Wellcome Trust (097922/Z/11/Z)
Medical Research Council (MC_PC_12009)
Leukemia & Lymphoma Society (7001-12)
Work in the authors’ laboratory is supported by grants from Leukaemia and Lymphoma
Research, the MRC, BBSRC, the Leukaemia and Lymphoma Society, Cancer Research UK,
the National Institute for Health Research Cambridge Biomedical Research Centre, and core
support grants by the Wellcome Trust to the Cambridge Institute for Medical Research and
Wellcome Trust & MRC Cambridge Stem Cell Institute. FSLN is the recipient of a Yousef
Jameel scholarship.