Cell competition: Winning out by losing notch
Taylor & Francis
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Alcolea Delgado, M., & Jones, P. (2015). Cell competition: Winning out by losing notch. Cell Cycle, 14 9-17. https://doi.org/10.4161/15384101.2014.988027
Cell competition where ‘loser’ cells are eliminated by neighbors with higher fitness is a widespread phenomenon in development. However, a growing body of evidence argues cells with somatic mutations compete with their wild type counterparts in the earliest stages of cancer development. Recent studies have begun to shed light on the molecular and cellular mechanisms that alter the competitiveness of cells carrying somatic mutations in adult tissues. Cells with a ‘winner’ phenotype create clones which may expand into extensive fields of mutant cells within normal appearing epithelium, favoring the accumulation of further genetic alterations and the evolution of cancer. Here we focus on how mutations which disrupt the Notch signaling pathway confer a ‘super competitor’ status on cells in squamous epithelia and consider the broader implications for cancer evolution.
carcinogenesis, cancer, esophagus, field change, progenitor, squamous, stem cell
We acknowledge the support of the MRC, the NC3Rs (National Center for the Replacement, Refinement and Reduction of Animals in Research), the Wellcome Trust (Project grant WT090334MA, to PHJ), Cancer Research UK (Program Grant C609/A17257, to PHJ) and a European Union Marie Curie Fellowship (PIEF-LIF-2007-220016, to MPA).
Medical Research Council (MC_UU_12022/3)
Cancer Research UK (C609/A17257)
External DOI: https://doi.org/10.4161/15384101.2014.988027
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246862
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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