The past, present, and future of Leishmania genomics and transcriptomics.
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Type
Article
Change log
Authors
Cantacessi, Cinzia https://orcid.org/0000-0001-6863-2950
Dantas-Torres, Filipe
Nolan, Matthew J
Otranto, Domenico
Abstract
It has been nearly 10 years since the completion of the first entire genome sequence of a Leishmania parasite. Genomic and transcriptomic analyses have advanced our understanding of the biology of Leishmania, and shed new light on the complex interactions occurring within the parasite-host-vector triangle. Here, we review these advances and examine potential avenues for translation of these discoveries into treatment and control programs. In addition, we argue for a strong need to explore how disease in dogs relates to that in humans, and how an improved understanding in line with the 'One Health' concept may open new avenues for the control of these devastating diseases.
Description
Keywords
Leishmania infantum, One Health, bioinformatics, genome, high-throughput sequencing, host-parasite interactions, leishmaniases, metazoonosis, sand fly, transcriptome, Animals, Gene Expression Profiling, Genome, Protozoan, Genomics, Humans, Leishmania, Leishmaniasis, Transcriptome
Journal Title
Trends Parasitol
Conference Name
Journal ISSN
1471-4922
1471-5007
1471-5007
Volume Title
31
Publisher
Elsevier Ltd
Publisher DOI
Sponsorship
Part of this article was conceived within the framework of of the
EurNegVec COST Action TD1303. Funding from the Isaac Newton Trust/
Wellcome Trust ISSF/University of Cambridge Joint Research Grants
Scheme to C.C. is gratefully acknowledged.