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dc.contributor.authorPauklin, Siim
dc.contributor.authorVallier, Ludovic
dc.date.accessioned2015-04-22T11:29:52Z
dc.date.available2015-04-22T11:29:52Z
dc.date.issued2015-02-15
dc.identifier.citationPauklin S, Vallier L, Development 2015, 142, 607-619, doi: 10.1242/dev.091769
dc.identifier.issn0950-1991
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247423
dc.description.abstractActivin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an overview of the mechanisms by which the Activin/Nodal signalling pathway governs stem cell function in these different stages of development. We describe recent findings that associate Activin/Nodal signalling to pathological conditions, focusing on cancer stem cells in tumorigenesis and its potential as a target for therapies. Moreover, we will discuss future directions and questions that currently remain unanswered on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.
dc.description.sponsorshipS.P. was supported by the EUFP7 grant InnovaLIV and an FEBS long-term fellowship. L.V. was supported by the ERC starting grant Relieve IMDs and the Cambridge Hospitals National Institute for Health Research Biomedical Research Centre.
dc.languageEnglish
dc.language.isoen
dc.publisherThe Company of Biologists
dc.subjectActivin
dc.subjectCell cycle
dc.subjectDifferentiation
dc.subjectNodal
dc.subjectPluripotency
dc.subjectStem cells
dc.titleActivin/Nodal signalling in stem cells.
dc.typeArticle
dc.description.versionThis is the accepted manuscript of a paper published in Development (Pauklin S, Vallier L, Development 2015, 142, 607-619, doi: 10.1242/dev.091769). The final version is available at http://dx.doi.org/10.1242/dev.091769
prism.endingPage619
prism.publicationDate2015
prism.publicationNameDevelopment
prism.startingPage607
prism.volume142
dc.rioxxterms.funderFP7
dc.rioxxterms.funderFEBS
dc.rioxxterms.funderERC
dc.rioxxterms.funderNIHR
rioxxterms.versionofrecord10.1242/dev.091769
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-02-15
dc.contributor.orcidVallier, Ludovic [0000-0002-3848-2602]
dc.identifier.eissn1477-9129
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G1000847)
pubs.funder-project-idMedical Research Council (G0800784)
pubs.funder-project-idMedical Research Council (G0701448)
pubs.funder-project-idEuropean Research Council (281335)
cam.issuedOnline2015-02-10
rioxxterms.freetoread.startdate2016-02-15


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