A NEWLY DEVELOPED TRI-LEAFLET POLYMERIC HEART VALVE PROSTHESIS
de, Gaetano Francesco
Journal of Mechanics in Medicine and Biology
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de, G. F., Bagnoli, P., Zaffora, A., Pandolfi, A., Serrani, M., Brubert, J., Stasiak, J., & et al. (2015). A NEWLY DEVELOPED TRI-LEAFLET POLYMERIC HEART VALVE PROSTHESIS. Journal of Mechanics in Medicine and Biology, 15 (1540009)https://doi.org/10.1142/S0219519415400096
The potential of polymeric heart valves (PHV) prostheses is to combine the hemodynamic performances of biological valves with the durability of mechanical valves. The aim of this work is to design and develop a new tri-leaflet prosthetic heart valve (HV) made from styrenic block copolymers. A computational finite element model was implemented to optimize the thickness of the leaflets, to improve PHV mechanical and hydrodynamic performances. Based on the model outcomes, 8 prototypes of the designed valve were produced and tested in vitro under continuous and pulsatile flow conditions, as prescribed by ISO 5840 Standard. A specially designed pulse duplicator allowed testing the PHVs at different flow rates and frequency conditions. All the PHVs met the requirements specified in ISO 5840 Standard in terms of both regurgitation and effective orifice area (EOA), demonstrating their potential as HV prostheses.
Heart valve prosthesis, finite element model, pulse duplicator, styrenic block copolymers
This work was funded by the British Heart Foundation (New Horizons NH/11/4/29059).
British Heart Foundation (SP/15/5/31548)
British Heart Foundation (NH/11/4/29059)
External DOI: https://doi.org/10.1142/S0219519415400096
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247880
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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