Trichotillomania (hair-pulling disorder) and skin-picking disorder are common neuropsychiatric disorders but are underrecognized by professionals. Affected individuals repeatedly pull out their own hair or pick at their skin, and these symptoms not only have a negative impact on the individual because of the time they occupy but also can lead to considerable physical disfigurement, with concomitant loss of self-esteem and avoidance of social activities and intimate relationships. The behaviors may also have potentially serious physical consequences. Trichotillomania and skin picking frequently co-occur, and both disorders commonly present with co-occurring depression or anxiety. Currently, behavioral therapy appears to be the most effective treatment of both disorders. Pharmacotherapy in the form of N-acetylcysteine or olanzapine may play a role in treatment as well.