Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells
Thaker, Youg Raj
Inflammation & Cell Signaling
Smart Science & Technology
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Thaker, Y. R., & Rudd, C. (2015). Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells. Inflammation & Cell Signaling, 2 (e613)https://doi.org/10.14800/ics.613
The transcription factor nuclear factor-kB (NF-kB) is critical for the induction of inflammatory responses in T-cells, survival and differentiation. Antigen receptor (TCR) and co-receptor CD28 are the central regulators of NF-kB activation in T-cells. Progress in understanding NF-kB activation in T-cells has occurred over the years with the identification of individual adapters such as ADAP and GRB-2 and enzymes such as PKC-θ that regulate NF-kB. However, little is known whether the engagement of distinct modules by the TCR and CD28 account for the cooperative effects of the two receptors in activating NF-kB. In this review, we discuss recent advances in our understanding of NF-kB regulation by TCR and CD28.
Adaptors, ADAP, VAV-1, GRB-2, NF-kB
This work was supported by Wellcome Trust Program Grant (PG) PKAG/504 to Principal Research Fellow (PRF) C.E. Rudd.
External DOI: https://doi.org/10.14800/ics.613
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248224
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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