Psychosocial factors associated with withdrawal from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) following one episode of repeat screening
International Journal of Gynecological Cancer
Lippincott Williams & Wilkins
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Jenkins, V., Fallowfield, L., Langridge, C., Barrett, J. K., Ryan, A., Jacobs, I., Kilkerr, J., et al. (2015). Psychosocial factors associated with withdrawal from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) following one episode of repeat screening. International Journal of Gynecological Cancer, 25 1519-1525. https://doi.org/10.1097/IGC.0000000000000507
Objective: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) aims to establish the efficacy of two different ovarian cancer screening schedules. The psychosocial sub study examines the psychological factors associated with the screening programme. Methods: Women aged 50 to 75 years from 16 UK gynaecological centres randomised to annual multimodal screening (MM), or ultrasound screening (US) groups were followed for seven years. Psychosocial data from women who withdrew from the study following a repeat screen were examined. Results: 16% (3499/21733) of women requiring a repeat screening test in addition to annual screen withdrew from the study; 12.9% (1560/12073) from the MM group, and 20.1% (1939/9660) from the US group; an estimated relative risk of withdrawal of 1.46 (95%CI: [1.36, 1.56]; p=<0.001) for the US arm. High anxiety trait and increased psychological morbidity significantly influenced withdrawal even when age, screening centre, and group were taken into account (p<0.001). The risk of withdrawal decreased significantly the longer a woman stayed in UKCTOCS, irrespective of the number of screens and intensity in the preceding year. Conclusions: Withdrawal rate was greater in women undergoing US screening and in those who had repeats earlier in UKCTOCS. Having a high predisposition to anxiety, high current state anxiety and above threshold general psychological morbidity all increased the withdrawal rate.
Ovarian cancer, population screening programme, withdrawal, anxiety, psychological morbidity, UKCTOCS
VF and JB were supported by the MRC (Unit Programme number U105261167 and grant number G0902100) and UM by National Institute for Health Research University College London Hospitals Biomedical Research Centre.
External DOI: https://doi.org/10.1097/IGC.0000000000000507
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248517
Attribution-NonCommercial 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by-nc/2.0/uk/
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