Mouse models of colorectal cancer as preclinical models
McIntyre, Rebecca E
Arends, Mark J
Adams, David J
Cancer Research UK Cambridge Institute, University of Cambridge
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McIntyre, R. E., Buczacki, S., Arends, M. J., & Adams, D. J. (2015). Mouse models of colorectal cancer as preclinical models. Bioessays, 37 909-920. https://doi.org/10.1002/bies.201500032
In this review, we discuss the application of mouse models to the identification and pre-clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large-scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross-species comparative ‘omics-based approaches to this problem. We highlight recent progress in modelling late-stage disease using mice, and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection.
mouse model, colorectal cancer, target identification, target validation, disease biomarker, 'ome, 'omics
REM, SJAB, MJA and DJA are funded by Cancer Research UK.
External DOI: https://doi.org/10.1002/bies.201500032
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248703
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/