A concise and scalable strategy for the total synthesis of dictyodendrin B based on sequential C–H functionalization
Pitts, Andrew K
Snell, Robert H
Angewandte Chemie International Edition
MetadataShow full item record
Pitts, A. K., O'Hara, F., Snell, R. H., & Gaunt, M. (2015). A concise and scalable strategy for the total synthesis of dictyodendrin B based on sequential C–H functionalization. Angewandte Chemie International Edition, 54 5451-5455. https://doi.org/10.1002/anie.201500067
A sequential C-H functionalization strategy for the synthesis of the marine alkaloid dictyodendrin B is reported. Our synthesis begins from commercially available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural product.
C-H functionalization, flow chemistry, metal catalysis, natural products, total synthesis
We are grateful to AstraZeneca, Pfizer, and EPSRC (A.K.P., F.O. and R.H.S.) and the ERC and EPSRC for fellowships (M.J.G.).
External DOI: https://doi.org/10.1002/anie.201500067
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248954