Show simple item record

dc.contributor.authorHuch Ortega, Meritxellen
dc.contributor.authorKoo, Bonkyoungen
dc.date.accessioned2015-09-03T11:15:59Z
dc.date.available2015-09-03T11:15:59Z
dc.date.issued2015-09-14en
dc.identifier.citationHuch & Koo. Development (2015) Vol. 142, pp. 3113-3125. doi: 10.1242/dev.118570en
dc.identifier.issn0950-1991
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/250464
dc.description.abstractIn vitro 3D cultures are emerging as novel systems with which to study tissue development, organogenesis and stem cell behaviour ex vivo. When grown in a 3D environment, embryonic stem cells (ESCs) self-organize into organoids and acquire the right tissue patterning to develop into several endoderm- and ectoderm-derived tissues, mimicking their in vivo counterparts. Tissue-resident adult stem cells (AdSCs) also form organoids when grown in 3D and can be propagated in vitro for long periods of time. In this review we discuss recent advances in the generation of pluripotent stem cell- and AdSC-derived organoids, highlighting their potential for enhancing our understanding of human development. We will also explore how this new culture system allows disease modeling and gene repair for a personalized regenerative medicine approach.
dc.description.sponsorshipM.H. is a Wellcome Trust Sir Henry Dale Fellow and is jointly funded by the Wellcome Trust and the Royal Society. B.-K.K. is supported by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society.
dc.languageEnglishen
dc.language.isoenen
dc.publisherCompany of Biologists
dc.subject3D-Organoid Cultureen
dc.subjectEmbryonic Stem Cellen
dc.subjectAdult Stem Cellen
dc.subjectDisease Modelingen
dc.subjectGenetic Engineeringen
dc.titleModeling mouse and human development using organoid culturesen
dc.title.alternative3D-organoid culturesen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from the Company of Biologists via http://dx.doi.org/10.1242/dev.118570en
prism.endingPage3125
prism.publicationDate2015en
prism.publicationNameDevelopmenten
prism.startingPage3113
prism.volume142en
dc.rioxxterms.funderWellcome Trust
rioxxterms.versionofrecord10.1242/dev.118570en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-09-14en
dc.contributor.orcidHuch Ortega, Meritxell [0000-0002-1545-5265]
dc.identifier.eissn1477-9129
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (101241/Z/13/Z)
pubs.funder-project-idWELLCOME TRUST (104151/Z/14/Z)
rioxxterms.freetoread.startdate2016-03-14


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record