Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals
Mehta, Puja R.
Goodyer, Ian M.
Fletcher, Paul C.
Proceedings of the National Academy of Sciences (PNAS)
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Teufel, C., Subramaniam, N., Dobler, V., Perez, J., Finnemann, J., Mehta, P. R., Goodyer, I. M., & et al. (2015). Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals. Proceedings of the National Academy of Sciences (PNAS), 112 (43), 13401-13406. https://doi.org/10.1073/pnas.1503916112
This is the author accepted manuscript. The final version is available from PNAS via http://dx.doi.org/10.1073/pnas.1503916112
Many neuropsychiatric illnesses are associated with psychosis, i.e., hallucinations (perceptions in the absence of causative stimuli) and delusions (irrational, often bizarre beliefs). Current models of brain function view perception as a combination of two distinct sources of information: bottom-up sensory input and top-down influences from prior knowledge. This framework may explain hallucinations and delusions. Here, we characterized the balance between visual bottom-up and top-down processing in people with early psychosis (study 1) and in psychosis-prone, healthy individuals (study 2) to elucidate the mechanisms that might contribute to the emergence of psychotic experiences. Through a specialized mental-health service, we identified unmedicated individuals who experience early psychotic symptoms but fall below the threshold for a categorical diagnosis. We observed that, in early psychosis, there was a shift in information processing favoring prior knowledge over incoming sensory evidence. In the complementary study, we capitalized on subtle variations in perception and belief in the general population that exhibit graded similarity with psychotic experiences (schizotypy). We observed that the degree of psychosis proneness in healthy individuals, and, specifically, the presence of subtle perceptual alterations, is also associated with stronger reliance on prior knowledge. Although, in the current experimental studies, this shift conferred a performance benefit, under most natural viewing situations, it may provoke anomalous perceptual experiences. Overall, we show that early psychosis and psychosis proneness both entail a basic shift in visual information processing, favoring prior knowledge over incoming sensory evidence. The studies provide complementary insights to a mechanism by which psychotic symptoms may emerge.
psychosis, predictive coding, top-down processing, schizophrenia
This work was carried out within the Wellcome Trust and Medical Research Council funded by BCNI and the CPFT. This study was supported by grants from the Wellcome Trust and the Bernard Wolfe Health Neuroscience fund (to P.C.F.).
External DOI: https://doi.org/10.1073/pnas.1503916112
This record's URL: https://www.repository.cam.ac.uk/handle/1810/251090
Attribution-NonCommercial 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by-nc/2.0/uk/
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