Forty Years of Clathrin-coated Vesicles.
Change log
Authors
Robinson, Margaret S
Abstract
The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975 was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered the molecular details of clathrin and its associated proteins, including how they assemble into a coated vesicle and how they select cargo. Unexpected connections have been found with signalling, development, neuronal transmission, infection, immunity and genetic disorders. But there are still a number of unanswered questions, including how clathrin-mediated trafficking is regulated and how the machinery evolved.
Description
Keywords
adaptin, adaptor, dynamin, endocytosis, sorting signals, trans-Golgi network, Animals, Cell Biology, Clathrin, Clathrin-Coated Vesicles, Coated Pits, Cell-Membrane, History, 20th Century, History, 21st Century, Humans, Models, Molecular, Protein Conformation, Protein Transport
Journal Title
Traffic
Conference Name
Journal ISSN
1398-9219
1600-0854
1600-0854
Volume Title
16
Publisher
Wiley
Publisher DOI
Sponsorship
Wellcome Trust (086598/Z/08/Z)
Wellcome Trust (100140/Z/12/Z)
Wellcome Trust (100140/Z/12/Z)