Multivariate data analysis and metabolic profiling of artemisinin and related compounds in high yielding varieties of Artemisia annua field-grown in Madagascar
Gromski, Piotr S
Journal of Pharmaceutical and Biomedical Analysis
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Suberu, J., Gromski, P. S., Nordon, A., & Lapkin, A. (2015). Multivariate data analysis and metabolic profiling of artemisinin and related compounds in high yielding varieties of Artemisia annua field-grown in Madagascar. Journal of Pharmaceutical and Biomedical Analysis, 117 522-531. https://doi.org/10.1016/j.jpba.2015.10.003
An improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) protocol for rapid analysis of co-metabolites of A. annua in raw extracts was developed and extensively characterized. The new method was used to analyse metabolic profiles of 13 varieties of A. annua from an in-field growth programme in Madagascar. Several multivariate data analysis techniques consistently show the association of artemisinin with dihydroartemisinic acid. These data support the hypothesis of dihydroartemisinic acid being the late stage precursor to artemisinin in its biosynthetic pathway.
Artemisia annua, multivariate data analysis, metabolic profiling
The research leading to these results has received funding from Engineering and Physical Sciences Research Council project “Closed Loop Optimization for Sustainable Chemical Manufacture” [EP/L003309/1].
External DOI: https://doi.org/10.1016/j.jpba.2015.10.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/251298
Creative Commons Attribution 4.0
Licence URL: http://creativecommons.org/licenses/by/4.0/
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