Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry
Chemistry - A European Journal
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Lücke, D., Dalton, T., Ley, S. V., & Wilson, Z. Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry. Chemistry - A European Journal, 22 4206-4217. https://doi.org/10.1002/chem.201504457
Flow chemistry has been successfully integrated into the synthesis of a series of cyclooligomeric depsipeptides of three different ring sizes including the natural products beauvericin (1a), bassianolide (2b) and enniatin C (1b). A reliable flow chemistry protocol was established for the coupling and macrocyclisation to form challenging N‐methylated amides. This flexible approach has allowed the rapid synthesis of both natural and unnatural depsipeptides in high yields, enabling further exploration of their promising biological activity.
cyclooligomeric depsipeptides, natural products, flow chemistry, macrocycles, peptides
The authors gratefully acknowledge the EPSRC for financial support (grants EP/K009494/1 and EP/K039520/1).
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External DOI: https://doi.org/10.1002/chem.201504457
This record's URL: https://www.repository.cam.ac.uk/handle/1810/253019
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/