A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
Browne, Duncan L
Reaction Chemistry & Engineering
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Poh, J., Browne, D. L., & Ley, S. (2016). A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. Reaction Chemistry & Engineering, 1 101-105. https://doi.org/10.1039/C5RE00082C
A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.
We are grateful to the Cambridge Home and European Scholarship Scheme (JSP) and EPSRC (DLB and SVL, grant numbers EP/K0099494/1 and EP/K039520/1) for financial support.
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External DOI: https://doi.org/10.1039/C5RE00082C
This record's URL: https://www.repository.cam.ac.uk/handle/1810/253104
Creative Commons Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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