Mechanisms of metabolic dysfunction in cancer-associated cachexia.
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Peer-reviewed
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Authors
Petruzzelli, Michele
Wagner, Erwin F
Abstract
Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the adipose tissue. This systemic syndrome, termed cancer-associated cachexia (CAC), is a major cause of morbidity and mortality. While once attributed solely to decreased food intake, the present description of cancer cachexia is a disorder of multiorgan energy imbalance. Here we review the molecules and pathways responsible for metabolic dysfunction in CAC and the ideas that led to the current understanding.
Description
Keywords
cancer-associated cachexia (CAC), metabolic failure, skeletal muscle atrophy, white adipose tissue (WAT) browning, Adipose Tissue, White, Cachexia, Carbohydrate Metabolism, Endocrine System, Humans, Inflammation, Lipid Metabolism, Liver, Muscular Atrophy, Neoplasms
Journal Title
Genes Dev
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Journal ISSN
0890-9369
1549-5477
1549-5477
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Publisher
Cold Spring Harbor Laboratory
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Sponsorship
EFW is supported by a grant from the Spanish Ministry of Economy (BFU2012-40230) and a European Research Council Advanced Grant (ERC FCK/2008/37).