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dc.contributor.authorRay, Sandipanen
dc.contributor.authorReddy, Akhileshen
dc.date.accessioned2016-01-22T17:20:57Z
dc.date.available2016-01-22T17:20:57Z
dc.date.issued2016-02-11en
dc.identifier.issn0265-9247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253453
dc.description.abstractIntegration of knowledge concerning circadian rhythms, metabolic networks, and sleep-wake cycles is imperative for unraveling the mysteries of biological cycles and their underlying mechanisms. During the last decade, enormous progress in circadian biology research has provided a plethora of new insights into the molecular architecture of circadian clocks. However, the recent identification of autonomous redox oscillations in cells has expanded our view of the clockwork beyond conventional transcription/translation feedback loop models, which have been dominant since the first circadian period mutants were identified in fruit fly. Consequently, non-transcriptional timekeeping mechanisms have been proposed, and the antioxidant peroxiredoxin proteins have been identified as conserved markers for 24-hour rhythms. Here, we review recent advances in our understanding of interdependencies amongst circadian rhythms, sleep homeostasis, redox cycles, and other cellular metabolic networks. We speculate that systems-level investigations implementing integrated multi-omics approaches could provide novel mechanistic insights into the connectivity between daily cycles and metabolic systems.
dc.description.sponsorshipABR is a Wellcome Trust Senior Clinical Fellow and receives funding from the Wellcome Trust (Grant No. 100333/Z/12/Z), the European Research Council (ERC Starting Grant No. 281348, MetaCLOCK), the European Molecular Biology Organization (EMBO) Young Investigators Programme, and the Lister Institute of Preventative Medicine. SR is supported by the Wellcome Trust.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcircadian rhythmsen
dc.subjectmetabolic networksen
dc.subjectnon-transcriptional oscillatoren
dc.subjectperoxiredoxinen
dc.subjectredox regulationen
dc.subjectsleep-wake cycleen
dc.subjectsystems biologyen
dc.titleCross-talk between circadian clocks, sleep-wake cycles, and metabolic networks: Dispelling the darknessen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Wiley via https://doi.org/10.1002/bies.201500056en
prism.endingPage405
prism.publicationDate2016en
prism.publicationNameBioEssaysen
prism.startingPage394
prism.volume38en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectid100333/Z/12/Z
rioxxterms.versionofrecord10.1002/bies.201500056en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-02-11en
dc.identifier.eissn1521-1878
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (100333/Z/12/Z)
pubs.funder-project-idEuropean Research Council (281348)
cam.orpheus.successThu Jan 30 12:55:22 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International