Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Asim, Mohammad
Massie, Charlie E
Neal, David E
Abstract
To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.
Description
Keywords
Androgen Receptor, chaperones, prostate cancer, therapeutic target
Journal Title
Molecular & Cellular Oncology
Conference Name
Journal ISSN
2372-3556
2372-3556
2372-3556
Volume Title
3
Publisher
Taylor & Francis
Publisher DOI
Sponsorship
This work was supported by a Cancer Research UK program grant (to DEN).