Quantitative BOLD imaging at 3T: Temporal changes in hepatocellular carcinoma and fibrosis following oxygen challenge
Priest, Andrew N
Bowden, David J
Journal of Magnetic Resonance Imaging
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Patterson, A., Priest, A. N., Bowden, D. J., Wallace, T., Patterson, I., Graves, M., & Lomas, D. (2016). Quantitative BOLD imaging at 3T: Temporal changes in hepatocellular carcinoma and fibrosis following oxygen challenge. Journal of Magnetic Resonance Imaging, 44 739-744. https://doi.org/10.1002/jmri.25189
Purpose: To evaluate the utility of oxygen challenge and report on temporal changes in blood oxygenation level-dependent (BOLD) contrast in normal liver, hepatocellular carcinoma (HCC) and background fibrosis. Materials and Methods: Eleven volunteers (9 male and 2 female, mean age 33.5, range 27–41 years) and 10 patients (9 male and 1 female, mean age 68.9, range 56–87 years) with hepatocellular carcinoma on a background of diffuse liver disease were recruited. Imaging was performed on a 3T system using a multi-phase, multi-echo, fast gradient echo sequence. Oxygen was administered via a Hudson mask after two minutes free-breathing. Paired t-tests were performed to determine if the mean pre- and post-O2 differences were statistically significant. Results: In patients with liver fibrosis (n=8) the change in T2* following O2 administration was elevated (0.88±0.582ms, range 0.03–1.69ms) and the difference was significant (p=0.004). The magnitude of the BOLD response in patients with HCC (n=10) was larger, however the response was more variable (1.07±1.458ms, range -0.93–3.26 ms), the difference was borderline significant (p=0.046). The BOLD response in the volunteer cohort was not significant (p=0.121, 0.59±1.162 ms, range -0.81–2.44 ms). Conclusions: This work demonstrates that the BOLD response following oxygen challenge within cirrhotic liver is consistent with a breakdown in vascular autoregulatory mechanisms. Similarly the elevated BOLD response within HCC is consistent with the abnormal capillary vasculature within tumors and the arterialization of the blood supply. Our results suggest that oxygen challenge may prove a viable BOLD contrast mechanism in the liver.
BOLD, liver, hepatocellular carcinoma, fibrosis
This study was supported by the Addenbrooke’s Charitable Trust, Cambridge’s Experimental Cancer Medicine Centre and a NIHR comprehensive Biomedical Research Centre award to Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge.
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External DOI: https://doi.org/10.1002/jmri.25189
This record's URL: https://www.repository.cam.ac.uk/handle/1810/253580