Breast milk nutrient content and infancy growth
Schoemaker, Marieke H
van, Tol Eric AF
MetadataShow full item record
Prentice, P., Ong, K., Schoemaker, M. H., van, T. E. A., Vervoort, J., Hughes, I., Acerini, C., & et al. (2016). Breast milk nutrient content and infancy growth. 105 641-647. https://doi.org/10.1111/apa.13362
Aim Benefits of human breast milk (HM) in avoiding rapid infancy weight-gain and later obesity could relate to its nutrient content. We tested the hypothesis that differential HM total calorie content (TCC) or macronutrient contents may be associated with infancy growth. Methods HM hindmilk samples were collected at ages 4-8 weeks from 614 mothers participating in a representative birth cohort, with repeated infancy anthropometry. HM triglyceride (fat), lipid analytes and lactose (carbohydrate) were measured by 1H-NMR, and protein content by the Dumas method. TCC and %macronutrients were determined. Results In 614 HM samples, fat content was: [median(IQR)]:2.6 (1.7-3.6)g/100mls, carbohydrate:8.6 (8.2-8.8)g/100mls, protein:1.2 (1.1-1.2)g/100mls; TCC:61.8 (53.7-71.3)kcal/100mls. HM of mothers exclusively breast-feeding vs. mixed-feeding was more calorific with higher %fat, lower %carbohydrate and lower %protein. Higher HM TCC was associated with lower 12m body mass index (BMI)/adiposity, and lower 3-12m gains in weight/BMI. HM %fat was inversely related to 3-12m gains in weight, BMI and adiposity, whereas %carbohydrate was positively related to these measures. HM %protein was positively related to 12m BMI. Conclusion HM analysis showed wide variation in %macronutrients. Although data on milk intakes were unavailable, our findings suggest functional relevance of HM milk composition to infant growth.
breast milk, macronutrients, nutrition, weight, growth
PP was supported by a MRC Clinical Training Fellowship (G1001995). The Cambridge Baby Growth Study has been supported by the European Union, the World Cancer Research Foundation International, the Medical Research Council, the NIHR Cambridge Comprehensive Biomedical Research Centre, the Newlife Foundation for disabled children, the Mothercare Group Foundation, and Mead Johnson Nutrition.
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Medical Research Council (MC_U106179472)
Embargo Lift Date
External DOI: https://doi.org/10.1111/apa.13362
This record's URL: https://www.repository.cam.ac.uk/handle/1810/253818