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dc.contributor.authorElliot, Micken
dc.date.accessioned2016-03-07T16:13:43Z
dc.date.available2016-03-07T16:13:43Z
dc.date.issued2016-03-04en
dc.identifier.citationM. G. Elliot. Journal of Reproductive Immunology (2016). DOI:10.1016/j.jri.2016.02.003en
dc.identifier.issn0165-0378
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/254218
dc.description.abstractIn this speculative paper, I consider the relationship between oxidative stress and the evolution of placentation in eutherian mammals. I argue that epitheliochorial placentation, in which fetal tissues remain separated from maternal blood throughout gestation, has evolved as a protective mechanism against oxidative stress arising from pregnancy, particularly in species with unusually long gestation periods and unusually large placentas. Human beings comprise an unusual species that has the life history characteristics of an epitheliochorial species, but exhibits hemochorial placentation, in which fetal tissues come into direct contact with maternal blood. I argue that the risk of preeclampsia has arisen as a consequence of the failure of human beings to evolve epitheliochorial placentation.
dc.description.sponsorshipI thank Pierre-Yves Robillard for his kind hospitality, and participants in the International Workshops on Reproductive Immunology, Immunological Tolerance and Immunology of Preeclampsia, for their helpful comments and suggestions. I thank St. John’s College, Cambridge, for supporting my attendance at the workshop.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/*
dc.subjectpreeclampsiaen
dc.subjecthemochorial placentationen
dc.subjectepitheliochorial placentationen
dc.subjectoxidative stressen
dc.titleOxidative stress and the evolutionary origins of preeclampsiaen
dc.typeArticle
dc.provenanceOA-7450
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.jri.2016.02.003en
prism.publicationDate2016en
prism.publicationNameJournal of Reproductive Immunologyen
dcterms.dateAccepted2016-02-24en
rioxxterms.versionofrecord10.1016/j.jri.2016.02.003en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-03-04en
dc.identifier.eissn1872-7603
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2017-03-04


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Attribution-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NoDerivatives 4.0 International