Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
Choudry, Fizzah Aziz
Stem Cells International
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Choudry, F. A., & Frontini, M. (2015). Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications. Stem Cells International, 2016 https://doi.org/10.1155/2016/5797521
Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriving clinical implications.
Fizzah Aziz Choudry is recipient of an MRC clinical fellowship (MR/K024043/1). Mattia Frontini is supported by the BHF Cambridge Centre of Excellence [RE/13/6/30180] and EU-FP7 project BLUEPRINT (282510).
EC FP7 NOE (282510)
External DOI: https://doi.org/10.1155/2016/5797521
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254471
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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