Microfluidic droplet facilitated hierarchical assembly for dual cargo loading and synergistic delivery
Coulston, Roger J
American Chemical Society
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Yu, Z., Zheng, Y., Parker, R., Lan, Y., Wu, Y., Coulston, R. J., Zhang, J., et al. (2016). Microfluidic droplet facilitated hierarchical assembly for dual cargo loading and synergistic delivery. 8 8811-8820. https://doi.org/10.1021/acsami.6b00661
Bottom-up hierarchical assembly has emerged as an elaborate and energy-efficient strategy for the fabrication of smart materials. Herein, we present a hierarchical assembly process, whereby linear amphiphilic block copolymers are self-assembled into micelles, which in turn are accommodated at the interface of microfluidic droplets via cucurbituril-mediated host-guest chemistry to form supramolecular microcapsules. The monodisperse microcapsules can be used for simultaneous carriage of both organic (Nile Red) and aqueous-soluble (fluorescein isothiocyanate-dextran) cargo. Furthermore, the well-defined compartmentalized structure benefits from the dynamic nature of the supramolecular interaction and offers synergistic delivery of cargos with triggered release or through photo-controlled porosity. This demonstration of premeditated hierarchical assembly, where interactions from the molecular to micro-scale are designed, illustrates the power of this route towards accessing the next generation of functional materials and encapsulation strategies.
Host Item: https://www.repository.cam.ac.uk/handle/1810/248506
This work was supported by the Engineering and Physical Sciences Research Council, Institutional Sponsorship 2012-University of Cambridge EP/K503496/1 and the Translational Grant EP/H046593/1; Y. Zheng and R. Parker were also funded from the European Research Council Starting Investigator grant ASPiRe (No. 240629) and the Isaac Newton Trust research grant No. 13.7(c). R. Coulston received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Proof of Concept Grant Agreement n. 297504; Y. Lan is supported by the CSC Cambridge Scholarship.
European Research Council (240629)
European Research Council (297504)
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External DOI: https://doi.org/10.1021/acsami.6b00661
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254632