Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu
Change log
Authors
Sum, TJ
Sum, TH
Galloway, WRJD
Spring, DR
Abstract
The concise and step-economical total syntheses of three hydroxyaurones and one polymethoxyflavone from readily available starting materials is described. A divergent synthetic strategy is employed, which centres on a common chalcone scaffold from which both the aurone and flavone frameworks can be accessed through the use of different oxidative cyclisation methods. These are the first reported total syntheses of these biologically interesting compounds.
Description
Keywords
flavonoids, hydroxyaurones, chalcones, divergent, total synthesis, natural products
Journal Title
Synlett
Conference Name
Journal ISSN
0936-5214
1437-2096
1437-2096
Volume Title
27
Publisher
Georg Thieme Verlag KG
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/J016012/1)
Royal Society (WM150022)
European Research Council (279337)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Royal Society (WM150022)
European Research Council (279337)
Engineering and Physical Sciences Research Council (EP/K039520/1)
We thank the Cambridge Commonwealth Trust for the awards of scholarships to T.J.S. and T.H.S. The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007– 2013)/ERC grant agreement no. [279337/DOS]. The authors also thank AstraZeneca, the European Union (EU), the Engineering and Physical Sciences Research Council (EPSRC), the Biotechnology and Biological Sciences Research Council (BBSRC), the Medical Research Council (MRC), and the Wellcome Trust for funding.