IP3 receptors: Take four IP3 to open.
American Association for the Advancement of Science
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Taylor, C., & Konieczny, V. (2016). IP3 receptors: Take four IP3 to open.. Science Signaling, 9 (422)https://doi.org/10.1126/scisignal.aaf6029
Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca(2+)release from the endoplasmic and sarcoplasmic reticulum. Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.
Binding Sites, Calcium, Calcium Signaling, Humans, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Ion Channel Gating, Models, Molecular, Molecular Structure, Protein Binding, Protein Domains
Wellcome Trust (101844/Z/13/Z)
External DOI: https://doi.org/10.1126/scisignal.aaf6029
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254785