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IP3 receptors: Take four IP3 to open.


Type

Article

Change log

Authors

Taylor, CW 
Konieczny, V 

Abstract

Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca(2+)release from the endoplasmic and sarcoplasmic reticulum. Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.

Description

Keywords

Binding Sites, Calcium, Calcium Signaling, Humans, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Ion Channel Gating, Models, Molecular, Molecular Structure, Protein Binding, Protein Domains

Journal Title

Science Signaling

Conference Name

Journal ISSN

1937-9145
1937-9145

Volume Title

9

Publisher

American Association for the Advancement of Science
Sponsorship
Wellcome Trust (101844/Z/13/Z)
Work from the authors’ laboratory is supported by the Wellcome Trust.