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IP3 receptors: Take four IP3 to open.

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https://www.repository.cam.ac.uk/handle/1810/254785

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HEFCE Exception sheet.pdf (86.94 KB)

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Article

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Abstract

Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca(2+)release from the endoplasmic and sarcoplasmic reticulum. Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.

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Keywords

Binding Sites, Calcium, Calcium Signaling, Humans, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Ion Channel Gating, Models, Molecular, Molecular Structure, Protein Binding, Protein Domains

Journal Title

Science Signaling

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Journal ISSN

1937-9145
1937-9145

Volume Title

9

Publisher

American Association for the Advancement of Science

Publisher DOI

https://doi.org/10.1126/scisignal.aaf6029

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Except where otherwised noted, this item's license is described as http://www.rioxx.net/licenses/all-rights-reserved
Sponsorship
Wellcome Trust (101844/Z/13/Z)
Work from the authors’ laboratory is supported by the Wellcome Trust.

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Scholarly Works - Pharmacology
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