IP3 receptors: Take four IP3 to open.
Change log
Authors
Taylor, CW
Konieczny, V
Abstract
Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca(2+)release from the endoplasmic and sarcoplasmic reticulum. Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.
Description
Keywords
Binding Sites, Calcium, Calcium Signaling, Humans, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Ion Channel Gating, Models, Molecular, Molecular Structure, Protein Binding, Protein Domains
Journal Title
Science Signaling
Conference Name
Journal ISSN
1937-9145
1937-9145
1937-9145
Volume Title
9
Publisher
American Association for the Advancement of Science
Publisher DOI
Sponsorship
Wellcome Trust (101844/Z/13/Z)
Work from the authors’ laboratory is supported by the Wellcome Trust.