Research data supporting '2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the Switch/Sucrose Non-Fermenting complex'.
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Dataset
Change log
Authors
Tallant, Cynthia
Monteiro, Octovia P.
Yapp, Clarence
Fuchs, Julian E.
Description
Data in support of the characterisation of compounds and their biological binding to proteins in the above manuscript. For synthesised compounds infra-red characterisation traces, HPLC traces where performed, and processed NMR files are provided. Raw files for the interaction of key compounds with PB1(5) and SMARCA2 and SMARCA4 proteins as measured by isothermal calorimetry are included. X-ray crystallography files are available through the Protein Data Bank.
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Software / Usage instructions
.pdf .sp - Spectrum IR (Perkin Elmer) .itc - Origin .mnova - MestreNova
Keywords
bromodomain, SWI/SNF, 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one, SMARCA
Publisher
University of Cambridge
Sponsorship
This work was supported by the EPSRC [grant numbers EP/K099494/1 EP/K039520/1], Wellcome Trust [grant number 092809/Z/10/Z] and the Cambridge PhD Training Programme in Molecular Medicine.