GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.
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Authors
Chen, Maxine M
O'Mara, Tracy A
Thompson, Deborah J
Painter, Jodie N
Australian National Endometrial Cancer Study Group (ANECS)
Abstract
Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
Description
Keywords
Chromosomes, Human, Pair 6, Endometrial Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide, White People
Journal Title
Hum Mol Genet
Conference Name
Journal ISSN
0964-6906
1460-2083
1460-2083
Volume Title
Publisher
Oxford University Press (OUP)
Publisher DOI
Sponsorship
Cancer Research Uk (None)
Cancer Research Uk (None)
National Health and Medical Research Council (1031333)
Cancer Research Uk (None)
Cancer Research UK (16565)
Cancer Research Uk (None)
National Health and Medical Research Council (1031333)
Cancer Research Uk (None)
Cancer Research UK (16565)
CRUK, Wellcome Trust, and numerous other funders. See manuscript for a complete list.