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dc.contributor.authorWise, Ten
dc.contributor.authorRadua, Jen
dc.contributor.authorVia, Een
dc.contributor.authorCardoner, Nen
dc.contributor.authorAbe, Oen
dc.contributor.authorAdams, TMen
dc.contributor.authorAmico, Fen
dc.contributor.authorCheng, Yen
dc.contributor.authorCole, JHen
dc.contributor.authorde, Azevedo Marques Périco Cen
dc.contributor.authorDickstein, DPen
dc.contributor.authorFarrow, TFDen
dc.contributor.authorFrodl, Ten
dc.contributor.authorWagner, Gen
dc.contributor.authorGotlib, IHen
dc.contributor.authorGruber, Oen
dc.contributor.authorHam, BJen
dc.contributor.authorJob, DEen
dc.contributor.authorKempton, MJen
dc.contributor.authorKim, MJen
dc.contributor.authorKoolschijn, PCMPen
dc.contributor.authorMalhi, GSen
dc.contributor.authorMataix-Cols, Den
dc.contributor.authorMcIntosh, AMen
dc.contributor.authorNugent, ACen
dc.contributor.authorO’Brien, Jen
dc.contributor.authorPezzoli, Sen
dc.contributor.authorPhillips, MLen
dc.contributor.authorSachdev, PSen
dc.contributor.authorSalvadore, Gen
dc.contributor.authorSelvaraj, Sen
dc.contributor.authorStanfield, ACen
dc.contributor.authorThomas, AJen
dc.contributor.authorvan, Tol MJen
dc.contributor.authorvan, der Wee NJAen
dc.contributor.authorVeltman, DJen
dc.contributor.authorYoung, AHen
dc.contributor.authorFu, CHen
dc.contributor.authorCleare, AJen
dc.contributor.authorArnone, Den
dc.date.accessioned2016-04-21T14:39:01Z
dc.date.available2016-04-21T14:39:01Z
dc.date.issued2016en
dc.identifier.citationWise et al. Molecular Psychiatry (2016)en
dc.identifier.issn1359-4184
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/255118
dc.description.abstractFinding robust brain substrates of mood disorders is an important target for research. The degree to which major depression and bipolar disorder are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry studies in major depression and bipolar disorder. We identified studies published up to January 2015 that compared grey matter in major depression (50 datasets including 4101 individuals) and bipolar disorder (36 datasets including 2407 individuals) using whole brain voxel-based morphometry. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex, and bilateral insula. Group comparisons indicated that findings of smaller grey matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal, and parietal regions were more substantial in major depression. These results suggest that major depression and bipolar disorder are characterized by both common and distinct patterns of grey matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.
dc.description.sponsorshipTW, AJC, AHY receive and DA has received funding support from the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. DA is supported by the Academy of Medical Sciences (reference AMS-SGCL8). ACN is funded through the National Institutes of Health. MJK is funded by an MRC CDA Fellowship (MR/J008915/1). MJvT was supported by a VENI grant (NWO grant number 016.156.077). MLP is funded by NIH grants R01MH1000, 1 P50 MH106435, R01 MH073953, R01 MH060952. FA has received funding from the Trinity College School of Medicine. JR received grant support from Instituto de Salud Carlos III - Subdirección General de Evaluación and the European Regional Development Fund (personal grant Miguel Servet CP14/00041 and project PI14/00292 integrated into the National Plan for research, development and innovation).
dc.languageEnglishen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.subjectdepressionen
dc.subjectbipolaren
dc.subjectgray matteren
dc.subjectimagingen
dc.subjectMRIen
dc.subjectaffective disordersen
dc.titleCommon and Distinct Patterns of Grey Matter Volume Alteration in Major Depression and Bipolar Disorder: Evidence from Voxel-Based Meta-Analysisen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Nature Publishing Group.en
prism.publicationDate2016en
prism.publicationNameMolecular Psychiatryen
dc.rioxxterms.funderNIHR
dc.rioxxterms.funderNIH
dc.rioxxterms.funderMRC
dc.rioxxterms.projectidR01MH1000
dc.rioxxterms.projectid1 P50 MH106435
dc.rioxxterms.projectidR01 MH073953
dc.rioxxterms.projectidR01 MH060952
dc.rioxxterms.projectidMR/J008915/1
dcterms.dateAccepted2016-03-23en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016en
dc.identifier.eissn1476-5578
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 12:54:45 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2017-06-30


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