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A structure parameter for porous pharmaceutical tablets obtained with the aid of Wiener bounds for effective permittivity and terahertz time-delay measurement.

Accepted version
Peer-reviewed

Repository DOI


Type

Article

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Authors

Chakraborty, Mousumi 
Ervasti, Tuomas 
Zeitler, J Axel 
Ketolainen, Jarkko 

Abstract

A structure parameter that can be used to predict the pattern of arrangement of porous inclusions in pharmaceutical tablets is introduced. By utilizing the effective refractive index of a pharmaceutical tablet obtained from terahertz time-domain measurements, we have shown that there exists a promising correlation between the calculated structural parameter and the porosity of training sets of pharmaceutical tablets, having well-defined characterization. Knowing of the structural arrangement, i.e. combined constituent skeletal-pore elements in series, parallel or mixed within porous media, could serve as a basis for understanding the ingress and permeation of liquids in such media. In the realm of pharmaceutical applications, such knowledge of the structural arrangement of air voids within a medicinal tablet could enable correlation with mechanical strength and dissolution behaviour in aqueous systems.

Description

Keywords

Effective medium, Indomethacin, Microcrystalline cellulose, Microstructures, Pharmaceutical tablet, Terahertz, Permeability, Porosity, Solubility, Stress, Mechanical, Surface Properties, Tablets, Technology, Pharmaceutical, Terahertz Spectroscopy

Journal Title

Int J Pharm

Conference Name

Journal ISSN

0378-5173
1873-3476

Volume Title

506

Publisher

Elsevier BV