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dc.contributor.authorSiebald, Carolineen
dc.contributor.authorKhandaker, Golamen
dc.contributor.authorZammit, Stanleyen
dc.contributor.authorLewis, Glynen
dc.contributor.authorJones, Peteren
dc.date.accessioned2016-05-17T11:37:32Z
dc.date.available2016-05-17T11:37:32Z
dc.date.issued2016-05-06en
dc.identifier.citationSiebald et al. Comprehensive Psychiatry (2016). doi: 10.1016/j.comppsych.2016.05.004en
dc.identifier.issn0010-440X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/256037
dc.description.abstractBackground Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. Method Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8 years. IQ was assessed by WISC-III also at 8 years. PEs, depressive and anxiety symptoms were assessed at 13 years. Logistic regression calculated odds ratio (OR) for PEs at 13 years associated with psychiatric disorders at 8 years. Linear regression calculated mean difference in IQ between groups with and without psychiatric disorder. Mediating effects of IQ, mood and anxiety symptoms on the psychiatric disorder-PEs relationship were examined. Results In total, 599 children were assessed to have a DSM-IV psychiatric disorder at 8 years (7.2%). These children compared with those without any psychiatric disorder performed worse on all measures of IQ; adjusted mean difference in total IQ − 6.17 (95% CI, − 7.86, − 4.48). Childhood psychiatric disorders were associated with PEs subsequently in adolescence; adjusted OR 1.96 (95% CI, 1.47–2.68). The association between psychiatric disorder and subsequent PEs was partly mediated by, independently, IQ deficit at 8 years and depressive and anxiety symptoms at 13 years. Conclusions The findings indicate adolescent PEs are associated with general cognitive ability and past and present psychopathological factors.
dc.description.sponsorshipProf Jones acknowledges support from the Wellcome Trust (095844/Z/11/Z & 088869/Z/09/Z) and NIHR (RP-PG-0606-1335). The UK Medical Research Council and the Wellcome Trust grant ref. 092731 and the University of Bristol provide core support for the ALSPAC cohort.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/uk/*
dc.titleAssociation between Childhood Psychiatric Disorders and Psychotic Experiences in Adolescence: a population-based longitudinal studyen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.comppsych.2016.05.004en
prism.publicationDate2016en
prism.publicationNameComprehensive Psychiatryen
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectid095844/Z/11/Z
dc.rioxxterms.projectid088869/Z/09/Z
dc.rioxxterms.projectidRP-PG-0606-1335
dc.rioxxterms.projectid092731
dcterms.dateAccepted2016-05-05en
rioxxterms.versionofrecord10.1016/j.comppsych.2016.05.004en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-05-06en
dc.contributor.orcidKhandaker, Golam [0000-0002-4935-9220]
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.identifier.eissn1532-8384
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCAMBS & PETERBOROUGH NHS FOUND TRUST (FB NHS/NIHR) (RP-PG-0606-1335)
pubs.funder-project-idAcademy of Medical Sciences (unknown)
pubs.funder-project-idWellcome Trust (088869/Z/09/Z)
pubs.funder-project-idWellcome Trust (095844/Z/11/Z)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
rioxxterms.freetoread.startdate2017-05-06


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